Epidemiological investigation of Childhood Asthma within the Childhood Asthma Prevention Study (CAPS)

Summary

childhood asthma prevention study

In 1997, The Childhood Asthma Prevention Study (CAPS) recruited babies at high risk of developing asthma and allergies because a parent and/or sibling had asthma or frequent wheeze. In this primary prevention trial, families were randomised to one or both interventions; house dust mite avoidance or dietary fatty acid supplementation in a factorial design.

A total of 616 families were enrolled into CAPS and the intervention phase of the trial continued through to the child’s 5th birthday. Concurrently we conducted regular clinical assessments at 18 months, 3 years, 5 years, 8 years, 11.5 years, 14 years and 17 years of age.

Supervisor(s)

Dr Brett Toelle, Professor Guy Marks

Research Location

Woolcock Institute of Medical Research
431 Glebe Point Road, Glebe NSW 2037

Program Type

Honours/Masters/Doctorate

Synopsis

To date CAPS has generated 64 peer-reviewed publications. We had at least 42 data collection contacts with these children/families from birth to 17 years of age which has produced an extensive and rich dataset. The dataset includes information about respiratory and allergy symptoms and diagnoses, atopy by skin prick test, lung function by spirometry and forced oscillation test, airway hyperresponsiveness by methacholine challenge and reversibility by post bronchodilator spirometry. Through blood tests we have collected DNA, immunological, inflammatory and fatty acid profile.

We also have an extensive array of exposure information including vaccinations, home environment such as heating, cooking and mould, dietary intake diaries and estimates of residential air pollution.

Proposals for secondary analyses on this dataset will require Human Research Ethics Committee approval.

Contact

Dr Brett Toelle, Research Leader

Email: brett.toelle@woolcock.org.au